Comparison Between Topical Minoxidil 5% Alone Versus Combined With Dutasteride (Topical 0.02% Through Microneedling Or Oral 0.5 Mg) In Treatment Of Androgenetic Alopecia

October 2024 in “ QJM ”

Maram Obeid, Nermeen Samy Abdel Fattah, Mona Mohamed Elfangary, Rania Mahmoud Al Husseni

minoxidil dutasteride androgenetic alopecia microneedling topical treatment oral treatment Rogaine Propecia

TLDR Combining Minoxidil with topical Dutasteride via microneedling is the most effective and safe treatment for hair loss.

This study compared the efficacy and safety of topical Minoxidil 5% alone versus combined with Dutasteride (either topical 0.02% through microneedling or oral 0.5 mg) in treating androgenetic alopecia (AGA) in 30 patients (24 males, 6 females). Over 16 weeks, all groups showed significant improvement, with the combination treatments (groups B and C) yielding better results in hair density and width than Minoxidil alone (group A). Group C, using topical Dutasteride with microneedling, showed the highest improvement and fewer systemic side effects compared to oral Dutasteride. The study concluded that combining Minoxidil with topical Dutasteride via microneedling is a promising and effective treatment for AGA with minimal side effects.

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