Efficacy and Safety of Platelet-Rich Plasma Therapy in Male Androgenetic Alopecia

October 2020 in “ Journal of Pakistan Association of Dermatology ”

Begum Bodrun Sultana, H K Paul

platelet-rich plasma androgenetic alopecia minoxidil hair density Hamilton-Norwood scale erythema PRP AGA Rogaine

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This study found that platelet-rich plasma therapy was more effective in increasing hair count than topical 5% minoxidil lotion in men with androgenetic alopecia. Our plain-language summary of this paper — not a Tressless recommendation.

The study conducted from October 2016 to October 2017 with 54 male patients with androgenetic alopecia (AGA) found that platelet-rich plasma (PRP) therapy was more effective than topical 5% minoxidil lotion in increasing hair count per square centimeter after 12 weeks of treatment. PRP therapy led to a significant increase in hair density of 19.29% at 3 months and 9.19% at 6 months, with better responses observed in patients with less advanced alopecia (Hamilton-Norwood scale grade II-III). While 81.48% of patients in the PRP group experienced mild pain and erythema, the side effects were not severe enough to discontinue treatment, and high patient satisfaction was reported. Despite these positive results, the study noted the limitations of a small sample size and the absence of long-term follow-up data.

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Research cited in this study

11 / 11 results

research Efficacy of Activated 3X Platelet-Rich Plasma in the Treatment of Androgenic Alopecia

3 citations , June 2017 in “PubMed”

In this study, autologous platelet-rich plasma prepared with Merisis One Step Gel Separation Technology improved hair counts, thickness, root strength, and overall alopecia in five patients without major adverse effects over three months.

research Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation

62 citations , October 2016 in “Dermatologic Therapy”

This study found that platelet-rich plasma was more effective for treating alopecia areata than topical 5% minoxidil, leading to earlier hair regrowth and reduction in hair abnormalities.

research Comparative Study of Efficacy of Platelet Rich Plasma Versus Minoxidil (5%-10%) in the Treatment of Androgenetic Alopecia in Males

2 citations , January 2016 in “Journal of Evolution of medical and Dental Sciences”

This study found that platelet rich plasma was more effective than minoxidil for treating androgenetic alopecia in males, with a good response observed in 76% of cases.

Outcome of Intra-Operative Injected Platelet-Rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomized Study in Forty Patients

research Outcome of Intra-Operative Injected Platelet-Rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomized Study in Forty Patients

39 citations , January 2016 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that intra-operative platelet-rich plasma therapy may enhance hair regrowth, increase graft density, and activate dormant follicles more effectively than normal saline in follicular unit extraction hair transplant patients.

research Efficacy of Platelet-Rich Plasma in Treatment of Androgenic Alopecia

74 citations , January 2015 in “Asian Journal of Transfusion Science”

This study found that platelet-rich plasma injections led to improvements in hair counts, thickness, and strength in patients with androgenic alopecia, showing promise as an effective treatment with no major adverse effects.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections may improve hair density and reduce hair loss in patients with androgenetic alopecia without significant side effects, but further research is needed to confirm efficacy.

research The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study

88 citations , December 2012 in “Journal of The European Academy of Dermatology and Venereology”

This study found that interfollicular injection of autologous CD34+ cell-containing PRP preparation improved hair count and thickness in patients with pattern hair loss, with better results than placental extract treatment.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations , March 2004 in “Journal of Dermatological Science”

This study found that minoxidil stimulates hair follicle growth by promoting dermal papilla cell survival and activating ERK and Akt pathways, which leads to increased proliferation and reduced cell death.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

23 citations , January 2002 in “Journal of Cutaneous Medicine and Surgery”

This study suggests that finasteride may affect hair follicle growth by altering the expression of caspases and XIAP, potentially regulating the anagen phase of hair growth.

research Finasteride and the Hair Cycle

26 citations , May 2000 in “Journal of The American Academy of Dermatology”

This study reports that finasteride increases hair count by reactivating resting follicles in men with frontal male pattern hair loss, with continuous clinical improvement due to thickening and elongation of hair even after hair count stabilization.