Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation
March 2017
in “Archives of Dermatological Research”
TLDR Sinapic acid may help hair growth by activating a specific cell pathway.
The document from March 20, 2017, investigated the effects of sinapic acid (SA) on hair growth by studying its impact on human hair follicle dermal papilla cells (hHFDPC). The study demonstrated that SA treatment led to the proliferation of hHFDPCs and activated the Akt signaling pathway. It also increased the expression of growth factors such as IGF-1 and VEGF, which are crucial for hair growth, and promoted cell cycle progression by increasing phospho-GSK-3ß and accumulation of ß-catenin. These findings suggest that SA has the potential to be an effective treatment for alopecia by promoting hair growth through the activation of Akt and the subsequent inactivation of the GSK-3B/ß-catenin pathway. The study did not specify the number of people or cells used in the research.
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