Topical Immunotherapy with Diphenylcyclopropenone in Pediatric Patients with Alopecia Areata: A Retrospective Study of 97 Patients

    August 2024 in “ Skin Health and Disease ”
    Farzad Esmaeili, Seyed Mohammad Vahabi, Mohammadsadegh Abdoli, Patrick Fazeli, Narges Ghandi, Leila Seddigh, Zeinab Aryanian, Ifa Etesami
    TLDR Topical immunotherapy with DPCP led to some hair regrowth in most pediatric alopecia areata patients, especially those with milder cases and longer treatment.
    A retrospective study involving 97 pediatric patients with alopecia areata (AA) evaluated the effectiveness of topical immunotherapy using diphenylcyclopropenone (DPCP). After one year of treatment, 8.8% of patients achieved a complete response, while 61.8% experienced some hair regrowth. The study found that patients with milder initial disease severity and those who underwent a longer duration of treatment showed better responses to the therapy.
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