Diphenylcyclopropenone in Patients with Alopecia Areata: A Critically Appraised Topic

October 2015 in “ British Journal of Dermatology ”

Rosanna A. Kuin, Phyllis I. Spuls, Jacqueline Limpens, Esther J van Zuuren

diphenylcyclopropenone alopecia areata randomized controlled trials

Studysummary This review reports very low quality evidence for the effectiveness and safety of treatments in extensive resistant alopecia areata and emphasizes the need for high-quality randomized controlled trials. Our plain-language summary of this paper — not a Tressless recommendation.

The document concluded that there was very low quality evidence supporting the effectiveness and safety of diphenylcyclopropenone in treating extensive resistant alopecia areata. It emphasized the need for well-designed and well-conducted randomized controlled trials with comprehensive reporting and high-quality methodological descriptions to better assess the treatment's efficacy and safety.

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Research cited in this study

6 / 6 results

research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

218 citations , April 2012 in “British Journal of Dermatology”

This updated guideline from the British Association of Dermatologists discusses current recommendations for managing alopecia areata but reports no new clinical research findings.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers

research Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers

13 citations , June 2010 in “Journal of dermatological treatment”

This study found that diphencyprone showed a significant clinical response for treating alopecia areata, while tacrolimus was not effective.

research Interventions for Alopecia Areata

2 citations , February 2009 in “Journal of Evidence-Based Medicine”

This review of randomized controlled trials for alopecia areata treatments found that none were significantly better than placebo in promoting long-term hair growth, with most trials being small and poorly reported.

research The Therapeutic Use of Topical Contact Sensitizers in Benign Dermatoses

60 citations , September 2001 in “British journal of dermatology/British journal of dermatology, Supplement”

This review discusses the use of contact sensitizers in topical immunotherapy for conditions like alopecia areata and viral warts, focusing on treatment methods, efficacy, and potential adverse effects, and reports no new clinical results.

research Allergic and Irritant Contact Dermatitis Compared in the Treatment of Alopecia Totalis and Universalis: A Comparison of the Value of Topical Diphencyprone and Tretinoin Gel

36 citations , March 1989 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, the authors compared topical diphencyprone and tretinoin gel for treating alopecia totalis and universalis, but the abstract does not report any definitive clinical results.