Dissolving Microneedles: Applications and Growing Therapeutic Potential

June 2022 in “ Journal of Controlled Release ”

Ziad Sartawi, Caroline Blackshields, Waleed Faisal

dissolving microneedles transdermal delivery therapeutic compounds valproic acid finasteride hair and scalp disorders hair growth inflammatory skin diseases microneedles transdermal patches Propecia

From the encyclopedia

Valproic acid →

an anticonvulsant repurposed for hair loss via histone inhibition

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This review discusses the advantages, applications, and current trends of dissolving microneedles for drug delivery across various therapeutic areas and reports no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

4 / 4 results

research Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia

33 citations , November 2019 in “Journal of Controlled Release”

In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.

research Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth

68 citations , March 2018 in “Biomaterials”

This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.

research Microneedle Applications in Improving Skin Appearance

131 citations , May 2015 in “Experimental Dermatology”

This review explores the development and cosmeceutical applications of microneedles for skin treatment, without reporting new clinical results, emphasizing safety and public perception as key factors for commercialization.

research Skin Signs of Systemic Diseases

21 citations , August 2011 in “Clinics in Dermatology”

This review discusses skin signs that can indicate systemic diseases and provides no new clinical results; it aims to aid physicians in diagnosing these conditions.