Success of Deuruxolitinib (Leqselvi™) in Extensively Treatment-Resistant Alopecia Universalis: A Case Report

    June 2026 in “ Cureus ”
    Simona Kogan, Moises Lutwak, Daniel Lutwak … Sunil Bhardwaj
    Studysummary In this reported case, a 30-year-old man with a long history of alopecia universalis experienced limited regrowth of eyebrows and eyelashes after six months of deuruxolitinib, despite unchanged scalp hair, suggesting site-specific potential for hair regrowth in challenging cases.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on cureus.com →
    Discuss this study in the Community →

    Research cited in this study 9

    1. Episodic Neuropathic-Like Musculoskeletal Pain Associated with Ritlecitinib Therapy in Alopecia Universalis: A Case Report Cureus · 2025
    2. Janus Kinase Inhibitors for Alopecia Areata: A Review of Clinical Data Frontiers in Immunology · 2025
    3. Significant Efficacy of Tofacitinib from China in the Treatment of Alopecia Areata: A Case Report Frontiers in Immunology · 2025
    4. Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024
    5. Perinevoid Alopecia: Report of Two Cases and Literature Review Clinical, cosmetic and investigational dermatology · 2023
    6. Immunology of Alopecia Areata Central-European Journal of Immunology/Central European Journal of Immunology · 2020
    7. Brigham Eyebrow Tool for Alopecia: A Reliable Assessment of Eyebrow Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2020
    8. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    9. Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases Dermatologic Therapy · 2011