Determination of Finasteride and Its Metabolite in Urine by Dispersive Liquid-Liquid Microextraction Combined with Field-Enhanced Sample Stacking and Sweeping

    March 2018 in “ Journal of Chromatography A ”
    Chun-Hsien Chen, Yu-Ying Chao, Yihui Lin, Yen-Ling Chen
    Studysummary This study describes an analytical technique combining field-enhanced sample stacking with dispersive liquid-liquid microextraction, offering improved sensitivity for detecting finasteride and its metabolite in urine samples from patients treated for androgenetic alopecia.
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    Research cited in this study 13

    1. Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss F1000Research · 2015
    2. High-Resolution Mass Spectrometric Investigation of the Phase I and II Metabolites of Finasteride in Pig Plasma, Urine, and Bile Xenobiotica · 2013
    3. Stability-Indicating Micellar Electrokinetic Chromatography Method for Determination of Finasteride in Pharmaceutical Preparations Journal of Liquid Chromatography & Related Technologies · 2013
    4. A Stability Indicating UPLC Method for Finasteride and Its Related Impurities American Journal of Analytical Chemistry · 2012
    5. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    6. Rapid Determination of Finasteride in Human Plasma by UPLC-MS/MS and Its Application to Clinical Pharmacokinetic Study Journal of Chromatography B · 2010
    7. In Vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites 2010
    8. The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men European Journal of Pharmaceutical Sciences · 2008
    9. Pathogenesis of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2004
    10. A Stability-Indicating HPLC Method to Determine Finasteride in a Tablet Formulation Journal of Liquid Chromatography & Related Technologies · 2002
    11. Finasteride Drugs · 1999
    12. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    13. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990