Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring

January 2021 in “ Stem Cell Research & Therapy ”

Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen, Xiaosong Chen

adipose-derived stem cell conditioned medium polysaccharide hydrogel hypertrophic scarring α-smooth muscle actin anti-fibrosis cytokine release

TLDR The combination of stem cell medium and hydrogel effectively reduces and improves hypertrophic scars.

The study examined the use of lyophilized adipose-derived stem cell concentrated conditioned medium (ADSCC-CM) combined with polysaccharide hydrogel to prevent hypertrophic scarring. Conducted on 12 male New Zealand rabbits, the research found that this combination, particularly the medium-dose ADSCC-CM with hydrogel (CM5+H), effectively reduced scar elevation and improved scar characteristics such as melanin, height, vascularity, and pliability. The ADSCC-CM downregulated α-smooth muscle actin (α-SMA) expression, indicating an anti-fibrosis effect, while the hydrogel served as a scaffold for sustained cytokine release. The study concluded that this combination could significantly enhance therapeutic outcomes in scar prevention, suggesting it as a promising strategy for hypertrophic scar prophylaxis.

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Research cited in this study

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Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations , November 2018 in “Nature Cell Biology”

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

research Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis

19 citations , March 2018 in “Journal of Investigative Dermatology”

The gene Msx2 is crucial for hair follicle regeneration during wound healing.

research Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

773 citations , August 2017 in “International Journal of Molecular Sciences”

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

research Fibrous Scaffolds Potentiate the Paracrine Function of Mesenchymal Stem Cells: A New Dimension in Cell-Material Interaction

182 citations , June 2017 in “Biomaterials”

Special fiber materials boost the healing properties of certain stem cells.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

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