TLDR Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
The study characterized a domain of high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1, identifying 24 KAP genes and 9 pseudogenes. These genes were categorized into families, including six novel ones, and exhibited varied expression patterns in hair follicles. Expression analysis revealed that 17 KAP genes were expressed in the hair cortex, matrix, and cuticle, with some showing distinct expression patterns between scalp and beard hair. The findings highlighted the complexity and diversity of KAP gene expression, suggesting evolutionary differences in KAP gene functionality among species and raising questions about the correlation between mRNA levels and protein synthesis.
24 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Two new proteins, hKAP1.6 and hKAP1.7, are found in the hair follicle cortex.
98 citations,
June 2001 in “Journal of biological chemistry/The Journal of biological chemistry” A cluster of sulfur-rich hair protein genes was found on chromosome 17.
235 citations,
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74 citations,
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12 citations,
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25 citations,
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28 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” 67 citations,
December 1990 in “The journal of cell biology/The Journal of cell biology” Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.