Unravelling the Threads of Central Centrifugal Cicatricial Alopecia

    March 2026 in “ Journal of Investigative Dermatology ”
    Rebecca L McCarthy, Edel A. O’Toole
    Studysummary Genetic factors, especially PADI3 gene variants, contribute to CCCA in women of African descent.
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    Research cited in this study 6

    1. Pathogenic Variants Affecting Peptidyl Arginine Deiminase 3 and Its Major Substrates Underlie Central Centrifugal Cicatricial Alopecia Journal of Investigative Dermatology · 2025
    2. A Hairy Situation: PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021
    3. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
    4. Association of Breast and Colorectal Cancer in Patients With Central Centrifugal Cicatricial Alopecia: A Retrospective, Cross-Sectional Pilot Study Journal of the American Academy of Dermatology · 2020
    5. Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
    6. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997