Study on Bioequivalence of Finasteride Tablets in Human Body

January 2005 in “ Zhongguo yaofang ”

Zhao Zhigang, Chenggang Wang

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finasteride bioequivalence pharmacokinetic parameters AUC C max t max HPLC serum concentrations Propecia

Studysummary This study found that domestic and imported finasteride tablets were bioequivalent in terms of their pharmacokinetic parameters and relative bioavailability in human volunteers.

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The study aimed to evaluate the bioequivalence of domestic and imported finasteride tablets in the human body. It involved 18 volunteers who were administered a single oral dose of 10 mg finasteride, and their serum concentrations were measured using HPLC. The results showed that the pharmacokinetic parameters, including AUC, C max, and t max, were similar between the two formulations. The relative bioavailability of the domestic tablets was 103.35% compared to the imported ones, indicating that both were bioequivalent.

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