Study on Human Bioequivalency of Two Preparations of Finasteride

    January 2005 in “ Journal of Elinical Research ”
    Cai Jing
    TLDR The two finasteride preparations are bioequivalent.
    The study investigated the pharmacokinetics and relative bioavailability of finasteride capsules and tablets in 18 healthy male volunteers. Each participant received a single 5 mg oral dose of either the test or control drug in a randomized cross-over design. The results showed that the area under the curve (AUC) for the control and test drugs were 355.7±63.7 and 363.1±65.6 ng·h/ml, respectively, with maximum concentrations (C_max) of 51.2±7.4 and 56.3±5.5 ng·h/ml, and time to reach maximum concentration (T_max) of 2.1±0.9 and 1.9±0.4 hours. The relative bioavailability of the test drug was 98.6±11.8%, indicating that the two preparations were bioequivalent.
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