Bioequivalence of Two Kinds of Finasteride Tablets in Healthy Volunteers

The study aimed to evaluate the bioequivalence of two different brands of finasteride tablets in healthy volunteers using a random crossover trial. The pharmacokinetic parameters, including AUC, T_max, C_max, and T_1/2, were measured after administering a single 40 mg oral dose of each brand. The results showed that the test and reference tablets had similar pharmacokinetic profiles, with AUC_0-24 and AUC_0-∞ values being nearly identical. The relative bioavailability (F_0-24 and F_0-∞) of the test tablets compared to the reference (Proscar) was approximately 103% and 101%, respectively. The study concluded that the two finasteride tablet formulations were bioequivalent.