Bioequivalence of Two Kinds of Finasteride Tablets in Healthy Volunteers
January 2004
in “
Chinese Journal of New Drugs and Clinical Remedies
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study concluded that two different brands of finasteride tablets are bioequivalent based on their pharmacokinetic parameters and relative bioavailability.
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The study aimed to evaluate the bioequivalence of two different brands of finasteride tablets in healthy volunteers using a random crossover trial. The pharmacokinetic parameters, including AUC, T_max, C_max, and T_1/2, were measured after administering a single 40 mg oral dose of each brand. The results showed that the test and reference tablets had similar pharmacokinetic profiles, with AUC_0-24 and AUC_0-∞ values being nearly identical. The relative bioavailability (F_0-24 and F_0-∞) of the test tablets compared to the reference (Proscar) was approximately 103% and 101%, respectively. The study concluded that the two finasteride tablet formulations were bioequivalent.