Bioequivalent Assessment of Finasteride Tablets

The study assessed the bioequivalence of locally manufactured finasteride tablets compared to imported ones in 18 healthy male volunteers. Participants received a single crossover dose of either the test or reference tablets, and serum finasteride concentrations were measured using HPLC. The pharmacokinetic parameters, including C_max, T_max, and AUC_0-t, showed no significant differences between the test and reference tablets. The relative bioavailability of the test tablets was 106.58%, indicating that the locally manufactured tablets were bioequivalent to the imported ones.