Determination of Finasteride in Human Plasma by LC-MS and Study on Its Bioequivalence

January 2007 in “ Pharmaceutical Journal of Chinese People's Liberation Army ”

Ning Wei

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finasteride LC-MS bioavailability pharmacokinetics plasma drug concentrations Propecia

Studysummary In this study, the researchers found that two formulations of finasteride tablets were bioequivalent in Chinese healthy male volunteers.

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The study investigated the pharmacokinetics and relative bioavailability of finasteride tablets in 20 healthy Chinese male volunteers using a random crossover design. Plasma drug concentrations were measured by LC-MS. The pharmacokinetic parameters, including AUC0-24, AUC0-∞, Cmax, Tmax, and T1/2, were similar between the tested and reference tablets. The relative bioavailability of the test tablet was 99.4%, indicating that the two finasteride tablets were bioequivalent.

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