Studies on the Pharmacokinetics and Bioequivalence of Domestic Finasteride Tablet in Healthy Volunteers
January 2004
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study concluded that domestic and imported finasteride tablets are bioequivalent, showing no significant differences in pharmacokinetic parameters among healthy volunteers. Our plain-language summary of this paper — not a Tressless recommendation.
The study aimed to evaluate the bioequivalence of domestic and imported finasteride tablets in 20 healthy volunteers using a randomized crossover design. Each participant received a single oral dose of 10 mg of either tablet, and finasteride concentrations were measured using the HPLC method. The pharmacokinetic parameters, including AUC0-24, Cmax, and Tmax, were similar for both products, with no significant differences observed (P>0.05). The relative bioavailability of the domestic tablet compared to the imported tablet was 100.73%. The study concluded that the domestic and imported finasteride tablets were bioequivalent.