Bioequivalence of Single Oral Administration of Finasteride Tablet and Capsule in Healthy Volunteers

January 2004

Zhao Ya

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finasteride bioequivalence reversed-phase high-performance liquid chromatography pharmacokinetic parameters half-life maximum concentration area under the curve Propecia

Studysummary This study found that the finasteride tablet and capsule are bioequivalent to the control finasteride tablet in healthy volunteers.

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The study aimed to evaluate the bioequivalence of finasteride in tablet and capsule forms in 24 healthy volunteers using a single oral dose of 15 mg. The research employed a reversed-phase high-performance liquid chromatography method to measure finasteride concentrations in plasma. The pharmacokinetic parameters, including half-life (T 1/2), time to reach maximum concentration (T max), maximum concentration (C max), and area under the curve (AUC), were similar across the tablet, capsule, and control tablet groups. The results indicated that the finasteride tablet and capsule were bioequivalent to the control finasteride tablet.

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