Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

    Pietro Gentile
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    TLDR Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.
    In 2019, a study was conducted on 35 patients (23 males and 12 females) aged 21-70 years, suffering from Androgenic Alopecia. The study used an autologous cellular method involving micrografts of human adipose tissue derived follicle stem cells (HD-AFSCs). The patients were treated with three injections at 45-day intervals. The results showed a significant improvement in hair density, with a mean increase of 33% ± 7.5% and 27% ± 3.5% at 23 and 44 weeks after the last injection, respectively. The study also found that the number of CD34+ cells, progenitor cells located in the outer root sheath of hair follicles, increased roughly 3-fold in the treated area compared to the baseline. The study concluded that HD-AFSCs contained in micro-grafts may represent a safe and effective alternative therapy option against hair loss, but further research is needed to fully understand the mechanisms and optimize the procedures.
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