Androgenetic alopecia in males: a histopathological and ultrastructural study
June 2009
in “Journal of Cosmetic Dermatology”
TLDR Hair loss in males involves inflammation, collagen buildup, and follicle damage, with severity increasing with age and baldness duration.
This document is a summary of six different studies that examined the histopathological and ultrastructural changes that occur in male androgenetic alopecia (AGA). The studies found that follicular microinflammation plays a role in the pathogenesis of AGA, and over time, there is increased deposition of collagen in the perifollicular sheath, resulting in marked fibrosis and sometimes complete destruction of the hair follicle in advanced cases. The severity of AGA was found to be highly correlated with age and duration of baldness, and a decrease in terminal hairs and an increase in vellus hairs were observed. The studies suggest that a better understanding of the miniaturization process may provide clues for identifying new approaches to treatment.
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