Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

    December 2020 in “ Cell Stem Cell
    Ryan S Samuel, Homa Majd, Mikayla N. Richter, Zaniar Ghazizadeh, Seyedeh M. Zekavat, Albertas Navickas, Jonathan Ramirez, Hosseinali Asgharian, Camille R. Simoneau, Luke R. Bonser, Kyung S. Koh, Miguel Garcia-Knight, Michel Tassetto, Sara Sunshine, Sina Farahvashi, Ali Kalantari, Wei Liu, Raul Andino, Hongyu Zhao, Pradeep Natarajan, David J. Erle, Melanie Ott, Hani Goodarzi, Faranak Fattahi
    Image of study
    TLDR Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
    The study from December 2020 explored the connection between androgen signaling and the severity of COVID-19 symptoms in men, particularly focusing on the regulation of ACE2, the receptor for SARS-CoV-2. The researchers conducted various analyses, including drug screening on human embryonic stem cell-derived cardiac cells and lung organoids, and examined clinical data from COVID-19 patients. They found that antiandrogenic drugs, which target the androgen signaling pathway, effectively reduced ACE2 expression and protected against SARS-CoV-2 infection. Clinical data supported these findings, showing that conditions associated with elevated androgen levels, such as prostate diseases, were significant risk factors for severe COVID-19. The study also suggested that genetic variants increasing androgen levels were linked to higher disease severity. The research indicates that antiandrogenic drugs could be potential therapeutic options for reducing the severity of COVID-19 in men. The document does not specify the number of people involved in the clinical aspect of the study.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Trestolone (MENT) as a nuclear treatment

      in Treatment  99 upvotes 2 years ago
      Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

      community The 'DHT itch' is real - notes from a casual bodybuilder

      in Chat  115 upvotes 1 month ago
      The "DHT itch" is real and likely due to inflammation at the hair follicle, exacerbated by increased testosterone or androgens. Treatments mentioned include dutasteride, minoxidil, finasteride, and various topical solutions.

      community Just find a cure already, I am totally done

      in Chat  161 upvotes 2 months ago
      The conversation is about hair loss treatments, with users recommending finasteride and minoxidil as effective solutions. Some users report side effects, but overall, the consensus is to use these treatments rather than waiting for a cure.

      community 4600 - result 9 month - Dr. Carman

      in Progress Pictures  255 upvotes 9 months ago
      A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  122 upvotes 11 months ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

    Similar Research

    5 / 1000+ results