Alopecia Areata: An Overview

January 2013 in “ Touro Scholar (Touro College) ”

Chaya Gestetner

alopecia areata Diphenylcyclopropenone topical sensitizer pathogenesis DPCP

TLDR DPCP works best for alopecia areata, but more research is needed for better treatments.

The review from 2013 aimed to identify the most effective treatment for alopecia areata, a condition with limited understanding and unsatisfactory treatment options at the time. After examining various studies, the author concluded that Diphenylcyclopropenone (DPCP), a topical sensitizer, showed the best results. However, the review emphasized the need for further research into the pathogenesis of alopecia areata to develop better treatment options.

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Research cited in this study

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research Evaluation of Anthralin in the Treatment of Alopecia Areata

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research Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata

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The Therapeutic Use of Topical Contact Sensitizers in Benign Dermatoses