Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers
June 2000
in “
Development
”
Research cited in this study
17 / 17 resultsresearch The Catalog of Human Hair Keratins
Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.
research WNT Signaling in the Control of Hair Growth and Structure
The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.
research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle
S100A3 protein is crucial for hair shaft formation in mice.
research Proanthocyanidins from Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells In Vitro and Convert Hair Cycle In Vivo
Grape seed proanthocyanidins can promote hair growth.
research Localization of Plasminogen Activator Inhibitor Type 2 in Hair and Nail: Implications for Terminal Differentiation
PAI-2 helps in the maturation and protection of hair and nail cells.
research Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination
Mouse Notch is important for determining cell roles in hair follicles.
research Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles
research The Secret Life of the Hair Follicle
Hair follicles create different cell layers and proteins, controlled by various molecules.
research Inductive Properties of Hair Follicle Cells
Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
research Hair-Specific Keratins: Characterization and Expression of a Mouse Type I Keratin Gene
research Differential Expression of Type I Hair Keratins
research Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation.
research A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin.
research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues
research Cloning and Characterization of a Mouse Type I Hair Keratin cDNA
research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles
research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins
Hair and nail cells share similar proteins, indicating a common differentiation pathway.
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The study identified a novel population of migratory epithelial cells expressing keratin 79 (K79) that played a crucial role in hair canal morphogenesis and regeneration. These K79+ keratinocytes moved outward from the hair germ into the epidermis before lumen formation in embryos and were similarly involved in hair regeneration in adult mice. During homeostasis, K79+ cells lined the hair follicle infundibulum, maintained by Lrig1+ stem cell-derived progeny. The study suggested that the upward movement of these cells sustained the infundibulum, and their loss was associated with acne progression. This research revealed significant long-distance cell movements in the hair follicle's life cycle, proposing a new mechanism for generating its hollow core through outward cell migration.