A Novel Topical Combination of Minoxidil and Spironolactone for Androgenetic Alopecia: Clinical, Histopathological, and Physicochemical Study

December 2020 in “ Dermatologic Therapy ”

Hamza Abdel-Raouf, Usama Farghaly Aly, Walid Medhat, Shimaa Abdalla Ahmed, Maha Nasr

minoxidil spironolactone androgenetic alopecia hair follicle density hair follicle diameter anagen hair telogen hair vellus hair Rogaine

TLDR Minoxidil and spironolactone combo effectively treats androgenetic alopecia, improving hair density and diameter.

A study found that a topical combination of minoxidil and spironolactone is an effective treatment for androgenetic alopecia, improving hair follicle density and diameter with no reported adverse effects. The combination was found to be more effective than either treatment alone, with a clinical response in 90% to 100% of patients. Histopathological examination of skin biopsy after treatment revealed a significant increase in anagen hair and a decrease in telogen and vellus hair. The study suggests that this combination treatment may be a promising option for treating androgenetic alopecia.

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The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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