Outer Root Sheath Cells Secrete Oxytocin for Hair Growth Promotion and Stem Cell Proliferation

    March 2026 in “ Journal of Bioscience and Bioengineering ”
    Tatsuto Kageyama, Ting Sun, Lei Yan … Junji Fukuda
    Studysummary Oxytocin from hair cells helps hair growth and stem cell increase.
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    Research cited in this study 12

    1. Effects of Oxytocin Receptor Agonists on Hair Growth Promotion Scientific Reports · 2024
    2. Cinnamic Acid Promotes Elongation of Hair Peg-Like Sprouting in Hair Follicle Organoids via Oxytocin Receptor Activation Scientific Reports · 2024
    3. Effects of Oxytocin on the Hair Growth Ability of Dermal Papilla Cells Scientific Reports · 2023
    4. Expansion Culture of Hair Follicle Stem Cells Through Uniform Aggregation in Microwell Array Devices ACS Biomaterials Science & Engineering · 2023
    5. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    6. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    7. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    8. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    9. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    10. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    11. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    12. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002