Identification of an Osteopontin-Derived Peptide That Binds Neuropilin-1 and Activates Vascular Repair Responses and Angiogenesis

June 2024 in “ Pharmacological Research ”

Yihong Chen, Chrysostomi Gialeli, Junyan Shen, Pontus Dunér, Björn Walse, Annette Duelli, Rhawnie Caing‐Carlsson, Anna M. Blom, John R. Zibert, Anna Hultgårdh Nilsson, Jan Alenfall, Chun Liang, Jan Nilsson

osteopontin-derived peptide FOL-026 neuropilin-1 NRP-1 vascular repair angiogenesis endothelial cell migration arterial smooth muscle cell proliferation VEGF alopecia vascular endothelial growth factor

Studysummary This study identified neuropilin-1 as the receptor for FOL-026 and showed that it stimulates angiogenesis and cell growth, suggesting potential for vascular repair and enhanced angiogenesis therapies.

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The study explores the osteopontin-derived peptide FOL-026, which binds to neuropilin-1 (NRP-1) and activates vascular repair and angiogenesis, showing potential for hair growth and cardiovascular health. FOL-026 enhances endothelial and arterial smooth muscle cell migration, proliferation, and apoptosis resistance, and improves blood flow in ischemic models. It activates VEGF expression and related signaling pathways, suggesting its therapeutic potential for conditions like alopecia, peripheral artery disease, and diabetic complications. The peptide's effects are mediated through NRP-1, with further studies needed to confirm its mechanisms and applications.

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