Keratin 6A Promotes Skin Inflammation Through JAK1-STAT3 Activation in Keratinocytes

    May 2025 in “ Journal of Biomedical Science ”
    Mengting Chen, Yaling Wang, M Wang … Ji Li
    Studysummary This study found that KRT6A expression increases after epidermal barrier disruption, worsening skin inflammation in disease conditions, and suggests that targeting KRT6A could offer a new treatment approach for inflammatory skin diseases linked to epidermal dysfunction.
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    Research cited in this study 3

    1. Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism Communications biology · 2022
    2. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2014
    3. Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis Journal of Investigative Dermatology · 2004