Is Methotrexate an Effective and Safe Treatment for Maintaining Hair Regrowth in People with Alopecia Totalis? A Critically Appraised Topic

    Ronald K. Browne, Lora Stewart, Hywel C Williams
    Studysummary This review found insufficient evidence to determine methotrexate's effectiveness for maintaining regrowth in extensive alopecia areata, and suggests its potential role in inducing regrowth when combined with corticosteroids.
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    Research cited in this study 18

    1. Alopecia Areata: Treatment Options and Efficacy Journal of the American Academy of Dermatology · 2017
    2. The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm Advances in Therapy · 2017
    3. Management of Alopecia Areata: Updates and Algorithmic Approach Journal of dermatology · 2017
    4. Methotrexate for the Treatment of Pediatric Alopecia Areata Journal of dermatological treatment · 2017
    5. High-Dose Pulsed Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata in Childhood JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2017
    6. Review of Treatment for Alopecia Totalis and Alopecia Universalis International Journal of Dermatology · 2017
    7. Low-Dose Systemic Methotrexate Therapy for Recalcitrant Alopecia Areata Annals of Dermatology · 2017
    8. Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis British Journal of Dermatology · 2016
    9. A Systematic Review of Pulse Steroid Therapy for Alopecia Areata Journal of the American Academy of Dermatology · 2016
    10. Efficacy and Safety of Methotrexate Combined with Low- to Moderate-Dose Corticosteroids for Severe Alopecia Areata Dermatology · 2016
    11. Diphenylcyclopropenone in Patients with Alopecia Areata: A Critically Appraised Topic British Journal of Dermatology · 2015
    12. Methotrexate in Severe Childhood Alopecia Areata: Long-Term Follow-Up Acta dermato-venereologica · 2015
    13. Efficacy and Safety of Methotrexate in Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2014
    14. British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012
    15. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012
    16. Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2011
    17. Interventions for Alopecia Areata Cochrane library · 2008
    18. Juvenile Versus Maturity-Onset Alopecia Areata: A Comparative Retrospective Clinical Study Clinical and Experimental Dermatology · 1989