Involvement of the Central Hypothalamic-Pituitary-Adrenal Axis in Hair Growth and Melanogenesis Among Different Mouse Strains

    October 2018 in “ PLoS ONE ”
    Qian Wang, Huali Wu, Jia Zhou … Jing Shang
    Studysummary This study found that chronic stress may inhibit hair follicle growth and melanogenesis in mice through modulation of the central HPA axis, with C57BL/6 mice appearing most sensitive to these effects.
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    Research cited in this study 11

    1. Alopecia Areata: Hyperactivity of the Hypothalamic–Pituitary–Adrenal Axis Is a Myth? Journal of the European Academy of Dermatology and Venereology · 2017
    2. Psychocutaneous Diseases: A Review of Psychiatric Disorders with Skin Manifestations and Their Prevalence in Dermatological Settings Journal of The American Academy of Dermatology · 2017
    3. Stress And The Hair Growth Cycle: Cortisol-Induced Hair Growth Disruption PubMed · 2016
    4. Chronic Stress Suppresses the Expression of Cutaneous Hypothalamic-Pituitary-Adrenocortical Axis Elements and Melanogenesis PLoS ONE · 2014
    5. A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation Pigment Cell & Melanoma Research · 2010
    6. Foot Shock Stress Prolongs the Telogen Stage of the Spontaneous Hair Cycle in a Non-Depilated Mouse Model Experimental Dermatology · 2007
    7. Neuroimmunoendocrine Circuitry of the Brain-Skin Connection Trends in Immunology · 2005
    8. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    9. Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor American Journal of Pathology · 2004
    10. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    11. Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994