Polydeoxyribonucleotide in Skincare and Cosmetics: Mechanisms, Therapeutic Applications, and Advancements Beyond Wound Healing and Anti-Aging

    April 2025 in “ Journal of Skin and Stem Cell ”
    Seyedeh Melika Akaberi, Kavita Sharma, Hamid Reza Ahmadi-Ashtiani, Mehdi Hedayati
    Studysummary This review discusses the potential of polydeoxyribonucleotide (PDRN) for various dermatological treatments and highlights its significant effects on wound healing, anti-aging, acne scars, and hair loss, but emphasizes the need for further clinical studies.
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    Research cited in this study 7

    1. An Effective Range of Polydeoxyribonucleotides Is Critical for Wound Healing Quality Molecular Medicine Reports · 2018
    2. Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster International Journal of Molecular Sciences · 2016
    3. The Antimycotic Agent Clotrimazole Inhibits Melanogenesis by Accelerating ERK and PI3K/Akt-Mediated Tyrosinase Degradation Experimental Dermatology · 2015
    4. Therapeutic Efficacy of Autologous Platelet-Rich Plasma and Polydeoxyribonucleotide on Female Pattern Hair Loss Wound Repair and Regeneration · 2014
    5. New Developments in Our Understanding of Acne Pathogenesis and Treatment Experimental dermatology · 2009
    6. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    7. Androgenetic Alopecia in Women Journal of Investigative Dermatology Symposium Proceedings · 2003