A Review: The Location, Molecular Characterization and Multipotency of Hair Follicle Epidermal Stem Cells

November 2004 in “ Annals of the Academy of Medicine Singapore ”

Dongrui Ma, EN Yang, ST Lee

hair follicle epidermal stem cells bulge region b1-integrin keratin 19 a6-integrin CD71 p63 CD34 wound epidermis epidermis sebaceous glands interfollicular keratinocyte stem cells dermal papilla mesenchyme cells hair growth

Studysummary This review examines the location and markers of hair follicle stem cells, finding that they are primarily located in the bulge region and can contribute to various skin structures, but challenges remain in distinguishing them from their progeny.

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research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

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The K15 promoter effectively targets stem cells in the hair follicle bulge.

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CD34 is a marker for isolating stem-like cells in mouse hair follicles.

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research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

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This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.

research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage

441 citations , May 1996 in “Journal of Cell Science”

This study found that keratin 19 may be a marker for skin stem cells, helping to characterize these cells in different conditions and potentially explaining variations in healing rates between children and adults.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

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In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.