61 citations
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November 2004 in “Annals of the Academy of Medicine Singapore”
Hairfolliclestemcells are mainly in the bulge region and can help repair skin and form hair and glands, but more research is needed to fully understand them.
Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermalstemcells. It also stresses the importance of patience when using these treatments.
Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.
PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hairfolliclestemcells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.
MCL-1 is important for hairfolliclestem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.