Inhibition of the Hippo Pathway by Verteporfin Reduces the Proliferation and Stemness of Rat Hair Follicle Neural Crest Stem Cells Under Hypoxia

    February 2025 in “ FASEB BioAdvances ”
    Weihai Liu, Suhua Chen, Xin Chen … Jun Yang
    Studysummary In this study, hypoxic conditions were found to enhance stemness in hair follicle neural crest stem cells, while inhibiting the Hippo pathway significantly decreased their proliferation.
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    Research cited in this study 7

    1. The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells Cell proliferation · 2023
    2. Exosomes From Hair Follicle Epidermal Neural Crest Stem Cells Promote Acellular Nerve Allografts To Bridge Rat Facial Nerve Defects Stem Cells and Development · 2022
    3. Therapeutic Potential of Hair Follicle-Derived Stem Cell Intranasal Transplantation in a Rat Model of Ischemic Stroke BMC neuroscience · 2022
    4. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    5. Olig2 Positive Cells Derived From Hair Follicle Neural Crest Stem Cells In Rats Journal of chemical neuroanatomy · 2020
    6. Progenitor Cells Expressing Nestin, a Neural Crest Stem Cell Marker, Differentiate Into Outer Root Sheath Keratinocytes Veterinary Dermatology · 2019
    7. Construction of Tissue-Engineered Nerve Conduits Seeded with Neurons Derived from Hair-Follicle Neural Crest Stem Cells Methods in molecular biology · 2016

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