Contraceptive Use in Acne

July 2014 in “ Clinics in Dermatology ”

Charlene Lam, Andrea L. Zaenglein

Studysummary This review examines the role of hormones in acne pathogenesis, the use of hormonal therapies for treatment, and the importance of contraceptive counseling during isotretinoin therapy, but reports no new clinical results.

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research Family Planning 2011: Better Use of Existing Methods, New Strategies, and More Informed Choices for Female Contraception

11 citations , June 2012 in “Human Reproduction Update”

This review discusses recent advancements in female contraception and covers topics like adapted regimens, non-invasive sterilization, and the promise of new methods, but it reports no new clinical findings.

research Hormonal Therapy for Acne: Why Not as First Line Therapy? Facts and Controversies

76 citations , December 2009 in “Clinics in Dermatology”

This review discusses the indications, contraindications, and potential for using hormonal therapy as a first-line treatment for acne in females, but reports no new clinical results.

research New Developments in Our Understanding of Acne Pathogenesis and Treatment

466 citations , June 2009 in “Experimental dermatology”

This review discusses recent advances in understanding acne pathobiology, highlighting the potential for developing new customized therapies, but it reports no new clinical findings.

research Hormonal Therapy for Acne

96 citations , September 2008 in “Seminars in Cutaneous Medicine and Surgery”

This review discusses the hormonal influences on acne's development in women and the therapeutic potential of hormonal treatments, but it reports no new clinical results.

research Combined Hormonal Contraception and Venous Thromboembolism

46 citations , January 2007 in “The European Journal of Contraception & Reproductive Health Care”

This review discusses the increased risk of venous thromboembolism associated with combined hormonal contraceptives, particularly noting higher risks with certain progestins like desogestrel, gestodene, and cyproterone acetate, but reports no new clinical findings.

research Acne and Sebaceous Gland Function

463 citations , September 2004 in “Clinics in dermatology”

This review discusses the development, function, and complex roles of sebaceous glands in acne and suggests future acne treatments should target inflammation and lipid production; it reports no new clinical results.

research Hirsutism and Acne in Polycystic Ovary Syndrome

169 citations , August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”

This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.

research Human Skin Is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)

289 citations , May 2003 in “Journal of Investigative Dermatology”

This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.

research Update and Future of Hormonal Therapy in Acne

78 citations , January 2003 in “Dermatology”

This article reviews hormonal therapy as a treatment for acne in women and suggests that emerging research on hormone synthesis and metabolism in the skin could guide future drug development.

research Inhibition of Skin 5α-Reductase by Oral Contraceptive Progestins In Vitro

78 citations , January 2000 in “Gynecological Endocrinology”

This study found that the progestins norgestimate and dienogest may help treat clinical hyperandrogeny in women by inhibiting skin 5 alpha-reductase activity with minimal androgenic potential.

Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone

research Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone

40 citations , January 1994 in “Skin Pharmacology and Physiology”

This study found that testosterone and 5α-dihydrotestosterone affect human sebocytes differently depending on the skin region, with spironolactone inhibiting their proliferation and counteracting androgen effects in facial sebocytes.

research Is The Metabolism Of Testosterone To 5α-Dihydrotestosterone Required For Androgen Action In The Skin?

14 citations , November 1982 in “British Journal of Dermatology”

This article discusses whether testosterone's metabolism to 5α-dihydrotestosterone is necessary for androgenic effects in the skin but reports no new experimental results.