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research Long-Term Response of Hirsutism and Other Hyperandrogenic Symptoms to Combination Therapy in Polycystic Ovary Syndrome

13 citations , June 2018 in “Journal of Womens Health”

This study found that in women with PCOS, suppressive therapy using spironolactone plus oral contraceptives improved hirsutism more effectively than either treatment alone, with initial scores predicting success.

research Polycystic Ovary Syndrome: Management of a Long-Term Condition in Primary Care

2 citations , January 2017 in “Cambridge University Press eBooks”

Manage PCOS in primary care with weight loss, psychological support, medication, and monitoring for health risks.

Polycystic Ovary Syndrome: A Comprehensive Review of Its Clinical Presentation, Comorbidities, Long-Term Complications, and Management

research Polycystic Ovary Syndrome: A Comprehensive Review of Its Clinical Presentation, Comorbidities, Long-Term Complications and Management

February 2025 in “International Journal of Pharmaceutical Research and Applications”

This article reviews the symptoms, diagnosis, and management of polycystic ovary syndrome, emphasizing lifestyle changes and medical interventions, but presents no new findings.

research A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile

4 citations , March 2018 in “Systems biology in reproductive medicine”

This study found that men born with very low birth weight had higher median serum estradiol levels but similar reproductive patterns compared to men born at term.

research Contraceptive use in acne

21 citations , July 2014 in “Clinics in Dermatology”

This review examines the role of hormones in acne pathogenesis, the use of hormonal therapies for treatment, and the importance of contraceptive counseling during isotretinoin therapy, but reports no new clinical results.

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Community Join

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community Long-term use of dutasteride may lead to male infertility by persistently impairing semen volume and sperm motility.

in Finasteride/Dutasteride 87 upvotes 1 year ago

Long-term use of dutasteride may impair semen volume and sperm motility, but these effects are often reversible after stopping the drug. Individual reactions vary, and more research is needed to understand the long-term impact on fertility.

community Why is Finasteride seen as “scary” for men, but hormonal birth control is totally normalized for women?

in Finasteride/Dutasteride 757 upvotes 1 year ago

Finasteride is seen as risky for men due to side effects like erectile dysfunction, while hormonal birth control for women is normalized despite its side effects. The discussion points out a double standard influenced by societal and gender norms.

community Don’t do like me. Don’t take a long break from Fin and Min

in Chat 124 upvotes 10 months ago

Stopping finasteride and minoxidil can cause significant hair shedding, so they should be continued indefinitely. Concerns about finasteride affecting fertility or causing birth defects are mostly unfounded, but some stop for personal reasons.

community Haunting study is making me considering cycling fin/dut

in Research/Science 158 upvotes 1 year ago

Concerns about the long-term effects of dutasteride and finasteride on fertility, with discussions on cycling these medications to mitigate risks. The conversation highlights skepticism about study methodologies and the importance of weighing treatment risks against potential fertility issues.

community Female diffuse hair loss on spiro with irregular periods (photos) + genetic hair loss

in Female 16 upvotes 1 year ago

A 34-year-old woman is experiencing diffuse hair loss and irregular periods, possibly due to long-term spironolactone use. She is considering minoxidil and finasteride for treatment and seeking medical advice for androgenic alopecia and hormonal imbalances.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

Is Osteopontin safe to use long-term in hair growth products? Osteopontin's long-term safety in hair growth products is not yet established.

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Fluocinolone

Can long-term use of Fluocinolone affect the health of hair follicles? There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.

learn Hydrocortisone

What are the risks of long-term hydrocortisone use on the scalp? Dermatology reviews describe long-term topical corticosteroid use as causing skin thinning, delayed healing, greater infection risk, possible suppression of the body's own cortisol, and rebound flares on stopping — and over-the-counter hydrocortisone labels limit use to about a week without a doctor's direction.

learn Rapamycin

Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

learn Azelaic Acid

Is azelaic acid safe to use daily long-term? Azelaic acid has a long tolerability record on facial skin in acne and rosacea, where side effects are local and usually mild — but for daily long-term scalp use the only trial is one six-month study in 26 women, in which mild itching was the main adverse effect, so long-term scalp safety is not established.

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