Microarray Gene Expression Analysis of Lesional Skin in Canine Pemphigus Foliaceus
February 2024
in “
Veterinary sciences
”
Studysummary This study found that canine pemphigus foliaceus skin lesions exhibit a distinct immune signature, with upregulated pro-inflammatory and Th17-related genes, showing similarities to human pemphigus. Further research using advanced sequencing is needed to better understand the disease's pathogenesis.
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This study analyzed gene expression in the skin lesions of 7 dogs with pemphigus foliaceus (PF) compared to 5 healthy controls, identifying 420 differentially expressed genes (338 upregulated, 82 downregulated). Key findings include elevated pro-inflammatory and Th17 markers, significant upregulation of Th1, Th2, and Th22 markers, and increased abundance of immune cells such as CD45 cells, NK/CD56dim cells, T-cells, neutrophils, dendritic cells, and CD8 T cells in PF lesions. These results suggest similarities between canine PF and human pemphigus, highlighting potential therapeutic targets and the need for further research using advanced sequencing techniques.
