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research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations, October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Adsorption of Diclofenac and PFBS on a Hair Keratin Dimer

December 2023 in “The journal of physical chemistry. B (1997 : Online)”

Human hair keratin might be good for filtering out harmful substances from water.

research Erectile Hemodynamics Assessment in ED Patients With Self-Diagnosed Post-Finasteride Syndrome

May 2023 in “The Journal of Sexual Medicine”

Men with self-diagnosed PFS-related ED have normal erectile hemodynamics.

research PSSD, PFS, PRSD: A Perspective for Aetiology and Treatment

April 2023

The paper suggests that a decrease in estrogen receptor activity may cause sexual dysfunction syndromes and proposes hormonal treatments.

research Notes from the Editor Emeritus: Coincidental Epigenetics or Post-Finasteride Syndrome?

November 2016 in “Hair transplant forum international”

The conclusion is that more research is needed to understand if the drug finasteride causes Post-Finasteride Syndrome or if it's due to individual genetic makeup.

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Community Join

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community A Summary of the Latest Research regarding PFS, and How Supplementing Allopregnanolone Might Protect Against It

in Chat 6 upvotes 9 months ago

Post Finasteride Syndrome (PFS) may result from epigenetic changes and gut microbiota alterations. Supplementing with Allopregnanolone might protect against these adverse effects.

community Why I believe PFS is not a "real" condition (and what I believe it is instead)

in Finasteride/Dutasteride 14 upvotes 2 years ago

The post argues that Post-Finasteride Syndrome (PFS) is likely not real and suggests symptoms may be due to mental health issues or the nocebo effect. The conversation includes personal experiences with finasteride, highlighting both positive and negative effects, and emphasizes consulting doctors and using reliable sources for medication.

community This is lagunaboy and I have fully recovered from PFS

in Finasteride/Dutasteride 5 upvotes 2 years ago

The user recovered from Post-Finasteride Syndrome (PFS) using a specific hormone protocol after trying finasteride and dutasteride. They now help others with PFS by reviewing blood work and offering personalized advice.

community MPB since 16. 31 now, recovering from PFS, and getting back in the game.

in Treatment 6 upvotes 4 years ago

User experienced hair loss since 16, used Fin, Minox, and Nizoral with success but stopped due to side effects. Now using Pur D'or shampoo, Rogaine foam, scalp massages, volumizing spray, and dermarolling for hair maintenance.

community Just had this wild thought come into my head.

in Satire 403 upvotes 9 months ago

The conversation is about the debate over the existence of Post-Finasteride Syndrome (PFS) and its symptoms, with some users skeptical about PFS and others discussing side effects like erectile dysfunction and gynecomastia from hair loss treatments like finasteride. Specific treatments mentioned include finasteride, viagra, and a joke about using a popsicle stick for erectile support.

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