In Vivo Alteration of the Keratin 17 Gene in Hair Follicles by Oligonucleotide-Directed Gene Targeting

    December 2003 in “ Experimental Dermatology ”
    Wu Fan, Kyung Chul Yoon
    Studysummary In this study, injecting chimeric RNA–DNA oligonucleotides into mice skin caused a temporary mutation in keratin 17, altering hair morphology, but the mutation was transient due to genetic compensation or cell replacement.
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    Research cited in this study 10

    1. Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia Genes & Development · 2002
    2. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002
    3. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    4. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and Its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000
    5. Localized In Vivo Genotypic and Phenotypic Correction of the Albino Mutation in Skin by RNA-DNA Oligonucleotide Nature biotechnology · 2000
    6. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    7. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    8. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    9. Keratin 17 Mutations Cause Either Steatocystoma Multiplex or Pachyonychia Congenita Type 2 British Journal of Dermatology · 1998
    10. Keratin 17 Gene Expression During the Murine Hair Cycle Journal of Investigative Dermatology · 1997

    Related research 6

    1. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    2. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    3. Keratins of the Human Hair Follicle International review of cytology · 2005
    4. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    5. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    6. The Extraction And Characterization Of Human Nail Keratin Journal of Dermatological Science · 1991