Preparation of Topical Bimatoprost with Enhanced Skin Infiltration and In Vivo Hair Regrowth Efficacy in Androgenic Alopecia

    January 2022 in “ Drug Delivery ”
    Laxman Subedi, Prashant Pandey, Jung-Hyun Shim … Jinwoo Park
    Studysummary In this study, a novel topical bimatoprost formulation (BIM-TF#5) significantly enhanced hair regrowth and increased dermal drug deposition in both human skin models and an androgenic alopecia mouse model compared to previous preparations.
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    Research cited in this study 13

    1. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    2. A Case of Contact Allergic Dermatitis to Topical Minoxidil Cureus · 2021
    3. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    4. Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2018
    5. Bimatoprost for the Treatment of Eyelash, Eyebrow, and Scalp Alopecia Expert Opinion on Investigational Drugs · 2017
    6. Hair Loss And Regeneration Performed On Animal Models Medicine and Pharmacy Reports · 2015
    7. Bimatoprost Versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study Dermatology · 2015
    8. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    9. The Prostamide-Related Glaucoma Therapy, Bimatoprost, Offers a Novel Approach for Treating Scalp Alopecias The FASEB Journal · 2012
    10. Enhancing the Growth of Natural Eyelashes: The Mechanism of Bimatoprost-Induced Eyelash Growth Dermatologic Surgery · 2010
    11. Management of Hypotrichosis of the Eyelashes: Focus on Bimatoprost Clinical, cosmetic and investigational dermatology · 2010
    12. Characterization of an In Vivo Model for the Study of Eyelash Biology and Trichomegaly: Mouse Eyelash Morphology, Development, Growth Cycle, and Anagen Prolongation by Bimatoprost British journal of dermatology/British journal of dermatology, Supplement · 2010
    13. Aphalangia Possibly Linked to Unintended Use of Finasteride During Early Pregnancy Annals of Saudi Medicine · 2009

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