CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata

    January 2024 in “ International Journal of Molecular Sciences ”
    Mei Zheng, M. N. Kim, Sang Gyu Park … Jong‐Hyuk Sung
    Studysummary This study found that subcutaneous injection of a CXCL12 neutralizing antibody significantly promoted hair growth in androgenic alopecia and inhibited hair loss in alopecia areata in mouse models, suggesting its potential as a promising treatment for hair loss.
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    Research cited in this study 12

    1. CXCL12 Inhibits Hair Growth Through CXCR4 Biomedicine & Pharmacotherapy · 2022
    2. Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges Molecules · 2022
    3. Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022
    4. Perifollicular Inflammation and Follicular Spongiosis in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    5. Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle Journal of Autoimmunity · 2021
    6. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    7. Pro-Inflammatory Vδ1+ T-Cells Infiltrates Are Present In And Around The Hair Bulbs Of Non-Lesional And Lesional Alopecia Areata Hair Follicles Journal of Dermatological Science · 2020
    8. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    9. Functional Regulation of Adipose-Derived Stem Cells by PDGF-D Stem Cells · 2014
    10. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    11. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    12. Mechanism of Action of Androgen in Hair Follicles Journal of dermatological science · 1994

    Related research 6

    1. Role of Low Dose Oral Minoxidil in the Treatment of Hair Loss: A Review Cosmoderma · 2021
    2. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    3. Treating Resistant Cases of Alopecia Universalis Journal of cosmetology & trichology · 2018
    4. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    5. Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women PubMed · 2002
    6. Treatment of Hair Loss The New England Journal of Medicine · 1999