A State-Of-The-Art Overview On (Epi)Genomics And Personalized Skin Rejuvenating Strategies

In this study, a systematic review highlighted the potential of exosomes in cosmetics and regenerative medicine for improving skin rejuvenation and addressing aging, while also pointing out existing challenges such as regulatory hurdles and the need for more clinical validation.

This review explores the potential of regenerative cosmetics, utilizing engineered skin tissues, to address aging, damage, and hair loss by enhancing collagen production, reducing wrinkles, and regenerating hair follicles, highlighting a transformative approach in dermocosmetics.

This review summarizes current literature associating mitochondrial dysfunction with dermatologic issues like skin aging, hair loss, and poor wound healing, noting potential benefits in targeting mitochondrial components for treatments.

In this review, the authors reported that exosomal miRNA-based therapies showed promising therapeutic effects on nine skin diseases in animal models, with enhanced outcomes observed when using miRNA-overexpressing exosomes compared to natural ones; however, no comparisons to standard treatments were available.

This study reviewed competing endogenous RNA networks related to skin aging and wound healing, finding mechanisms like UVB-induced senescence and photoaging, as well as potential therapeutic targets for improving skin health and recovery.

This study's overview highlights that lifestyle factors like nutrition, sleep, physical activity, and social interactions can significantly enhance skin health with aging. The authors suggest social media campaigns promoting these habits could potentially improve skin well-being in the future.

This review found that among emerging technologies for skin anti-aging, stem cell therapies using recipient chimerism might be more beneficial than CRISPR-Cas9 and other current innovations, though further studies on safety and efficacy are needed.

This study found that RCS-01 cell therapy for aged skin was well tolerated and associated with increased gene expression related to extracellular matrix homeostasis, suggesting potential skin improvement.

This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.