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    Keratin 15 Promotes a Progenitor Cell State in Basal Keratinocytes of Skin Epidermis

    February 2025 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Catherine J. Redmond, Stephen R. Steiner, Erez Cohen … Pierre A. Coulombe

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study proposes a model suggesting that the ratio of keratin 15 to keratin 14 in epidermal keratinocytes promotes a progenitor state and opposes differentiation, based on insights from both cell culture and transgenic mouse models.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 15

    1. Significance of Stress Keratin Expression in Normal and Diseased Epithelia iScience · 2024
    2. Revisiting the Significance of Keratin Expression in Complex Epithelia Journal of cell science · 2022
    3. Klhl24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2022
    4. Diverse Mechanisms for Endogenous Regeneration and Repair in Mammalian Organs Nature · 2018
    5. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013
    6. Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2009
    7. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    8. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    9. Location and Phenotype of Human Adult Keratinocyte Stem Cells of the Skin Differentiation · 2004
    10. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    11. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    12. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999
    13. Expression of the Intermediate Filament Keratin Gene K15 in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998
    14. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996
    15. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989