Epidermal Retinol Dehydrogenases Cyclically Regulate Stem Cell Markers and Clock Genes and Influence Hair Composition

April 2024 in “ Communications biology ”

Kelli R. Goggans, Olga V. Belyaeva, Alla Klyuyeva, Jacob Studdard, Aja Slay, Ruchi M. Newman, Christine VanBuren, Helen B. Everts, Natalia Y. Kedishvili

retinol dehydrogenases RDHEs Vitamin A metabolism hair follicle cycling hair composition stem cell markers clock genes hair growth awl hairs Vitamin A

Studysummary The researchers reported that disrupting ATRA signaling by deleting RDHE genes in the hair follicle led to altered hair follicle cycles, composition, and gene expression, indicating RDHEs' role in hair follicle signaling coordination.

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