Immune Privilege and Alopecia Areata

April 2010 in “ Expert review of dermatology ”

Taisuke Ito, Masaharu Takigawa

immune privilege alopecia areata hair follicles MHC class Ia antigens immunosuppressive agents anagen stage bulge area indoleamine 2,3-dioxygenase CD200 cicatricial alopecia IP HFs MHC class I

Studysummary This article discusses the immune privilege in hair follicles and suggests that restoring its collapse might be an effective strategy for treating alopecia areata and cicatricial alopecia, but it reports no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

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This study suggests that human hair follicles may actively suppress natural killer cells, which contrasts with the observed defects in NK cell regulation in alopecia areata.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

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research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege

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This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations , August 2005 in “Autoimmunity Reviews”

This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.

Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

This study found that psychoemotional stress disrupts hair growth in mice by terminating anagen and suggests a potential pathway for pharmacological management of stress-related hair loss in humans.

Towards a Molecular Understanding of Hair Loss and Its Treatment

research Postmenopausal Frontal Fibrosing Alopecia

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This study observed that progressive frontal recession in postmenopausal women may exhibit features of fibrosing alopecia, suggesting a distinct reaction pattern from typical lichen planopilaris.