Antiandrogens: Clinical Applications

November 1990 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

F Sciarra, Vincenzo Toscano, G Concolino, F. Di Silverio

antiandrogens cyproterone acetate ethinyl-estradiol spironolactone hirsutism acne oral contraceptives benign prostatic hyperplasia prostatic carcinoma flutamide nuclear receptors DHT androgen blockade CPA SPL BPH FLU

From the encyclopedia

Cyproterone →

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

Spironolactone →

powerful topical and oral anti-androgen used mostly by women

Studysummary This abstract reviews the use and effects of various antiandrogens, finding clinical benefits in treating hyperandrogenism in women and improvements in urinary symptoms or cancer management in men, but it reports no new clinical results.

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Research cited in this study

10 / 10 results

research Regulation of Androgen Receptor and 5α-Reductase in the Skin of Normal and Hirsute Women

35 citations , May 1986 in “Clinics in endocrinology and metabolism”

This study concludes that high skin 5α-reductase activity may contribute to hirsutism, but the specific regulatory mechanisms and genetic factors remain unclear.

research Treatment of Hirsutism and Acne with Cyproterone Acetate

43 citations , May 1986 in “Clinics in Endocrinology and Metabolism”

This review examines androgen status in male and female obesity and its influence on the metabolic syndrome, but reports no new clinical results.

research Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications

53 citations , October 1984 in “Endocrine reviews”

This review highlights that idiopathic hirsutism is characterized by local hyperandrogenization affecting hair growth, without other signs of hyperandrogenism, and shows no new results; racial differences in prevalence are noted but not in androgenic steroids.

research Treatment of Hirsutism With Spironolactone

183 citations , March 1982 in “JAMA”

This study reported that spironolactone at 200 mg/day significantly improved facial hair growth in women with hirsutism and showed a sustained reduction in ovarian androgens over one year.

research A Novel Use of Spironolactone: Treatment of Hirsutism

124 citations , September 1980 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that spironolactone significantly reduced hair growth in hirsute women, with noticeable effects in 3-5 months, and decreased serum testosterone levels in all participants.

research New Therapeutic Approach to the Hirsute Patient

60 citations , September 1979 in “Fertility and sterility”

This study found that spironolactone reduced testosterone production and urinary 17-ketosteroid excretion, leading to a decrease in hair growth rate and a change in hair texture in women.

research Spironolactone Therapy for Hirsutism in a Hyperandrogenic Woman

39 citations , November 1978 in “Annals of internal medicine”

This brief report discusses spironolactone used as a treatment for hirsutism in a hyperandrogenic woman, offering no new clinical findings and focusing on its antiandrogenic properties.

research Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism

232 citations , June 1975 in “Journal of Steroid Biochemistry”

In this study, a treatment regimen combining cyproterone acetate and ethinyl estradiol significantly improved acne and seborrhoea in most women after three months, but had varied effects on hirsutism and alopecia.

research The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-Androgen Cyproterone Acetate for Therapy

58 citations , July 1974 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that cyproterone acetate, given with ethinyl oestradiol, significantly reduced hirsutism in women after 12 months, although improvements reversed once cyproterone acetate was stopped.

research Biological Activity of Antiandrogens

51 citations , June 1970 in “British journal of dermatology/British journal of dermatology, Supplement”

This review discusses the biology of antiandrogens and highlights available bioassay models to predict their therapeutic effects on human skin, reporting no new clinical results.