The Preventive Effect of Vitamin D3 on Radiation-Induced Hair Toxicity in a Rat Model

    November 2005 in “ Life sciences ”
    Bahar Baltalarlı, Ferda Bir, Neşe Çallı Demirkan, Gülçin Abban
    Studysummary This study indicates that vitamin D3 administration may protect rat hair follicles from radiation-induced damage, as evidenced by maintained follicle numbers and increased Vitamin D receptor activity in treated skin.
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    Research cited in this study 12

    1. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    2. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    3. Molecular Genetic and Endocrine Mechanisms of Hair Growth Hormone Research in Paediatrics · 2003
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    5. Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors Science · 2001
    6. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice Endocrinology · 2000
    7. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    8. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998
    9. Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    10. Panax Ginseng Prevents Apoptosis in Hair Follicles and Accelerates Recovery of Hair Medullary Cells in Irradiated Mice PubMed · 1998
    11. The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed Journal of bone and mineral research · 1998
    12. Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone PubMed · 1994