Anti-Alopecia Activity of Alkaloids from Noni Fruit Against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

    December 2022 in “ Pharmaceuticals ”
    Laila Susanti, Resmi Mustarichie, Eli Halimah … Yustinus Maladan
    Studysummary This study found that a sub-fraction of Noni fruit, FEA-3, showed hair growth-promoting effects in a rabbit model of androgenic alopecia, similar to Minoxidil.
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    Research cited in this study 16

    1. Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Merremia Peltata as a Potential Anti-Alopecia Treatment Journal of advanced pharmaceutical technology & research · 2021
    2. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    3. Herbal Preparations for the Treatment of Hair Loss Archives of Dermatological Research · 2019
    4. Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways Biological & Pharmaceutical Bulletin · 2018
    5. Gas Chromatography Coupled to Mass Spectrometry Characterization, Anti-Inflammatory Effect, Wound-Healing Potential, and Hair Growth-Promoting Activity of Algerian Carthamus Caeruleus L (Asteraceae) Indian Journal of Pharmacology · 2018
    6. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    7. Characteristics And Alopecia Activity Of Pakis Gajah (Angiopteris Evecta) Growing In Galunggung Mountainside, West Java Asian journal of pharmaceutical and clinical research · 2017
    8. Experimental and Early Investigational Drugs for Androgenetic Alopecia Expert Opinion on Investigational Drugs · 2017
    9. The Diagnosis and Treatment of Hair and Scalp Diseases Deutsches Arzteblatt International · 2016
    10. Evaluation of Hair Growth Promoting Activity of Phyllanthus Niruri PubMed · 2015
    11. Hair Growth Promotion Activity and Its Mechanism of Polygonum Multiflorum Evidence-based Complementary and Alternative Medicine · 2015
    12. Effect of Adiantum Capillus-Veneris Linn on an Animal Model of Testosterone-Induced Hair Loss PubMed · 2014
    13. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    14. An Atlas of Hair Pathology with Clinical Correlations CRC Press eBooks · 2012
    15. Promotion Effect of Norgalanthamine, a Component of Crinum Asiaticum, on Hair Growth European Journal of Dermatology · 2010
    16. Animal Models of Androgen-Dependent Disorders of the Pilosebaceous Apparatus Archives of dermatological research · 1989

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