Cardiovascular Toxicities of Androgen Deprivation Therapy

April 2021 in “ Current Treatment Options in Oncology ”

Azariyas A. Challa, Adam Calaway, Jennifer Cullen, Jorge García, Nihar R. Desai, Neal L. Weintraub, Anita Deswal, Shelby Kutty, Ajay Vallakati, Daniel Addison, Ragavendra R. Baliga, Courtney Campbell, Avirup Guha

androgen deprivation therapy GnRH antagonists GnRH agonists prostate cancer

Studysummary This review discusses cardiovascular risks associated with androgen deprivation therapy in prostate cancer patients and highlights ongoing research, including the potential reduced COVID-19 susceptibility, but reports no new results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Male Balding Is a Major Risk Factor for Severe COVID-19

29 citations , July 2020 in “Journal of The American Academy of Dermatology”

In this study, researchers found that severe androgenic alopecia in hospitalized men was associated with a higher likelihood of testing positive for COVID-19.

research Androgenetic Alopecia Present in the Majority of Patients Hospitalized with COVID-19: The 'Gabrin Sign'

119 citations , May 2020 in “Journal of The American Academy of Dermatology”

This study observed a high prevalence of androgenetic alopecia in patients hospitalized with severe COVID-19, with 79% of men and 42% of women affected, suggesting a potential link between androgen sensitivity and COVID-19 severity.

A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity

research A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity

134 citations , April 2020 in “Journal of Cosmetic Dermatology”

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

research Androgenic Effects on Ventricular Repolarization

64 citations , August 2019 in “Circulation”

This study found that men receiving enzalutamide and other androgen-deprivation therapies may be at increased risk for QT prolongation and torsades de pointes.

research Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

60 citations , July 2018 in “Circulation”

This study found that hypogonadism in men can be a reversible risk factor for torsades de pointes (TdP), with testosterone replacement potentially preventing TdP recurrence.