Nociceptive and Non-Nociceptive Roles of TRPV3 and Its Druggability
January 2012
in “
Methods in pharmacology and toxicology
”
TRPV3 keratinocytes thermal nociception skin morphology hair morphology TRPV3 antagonists thermal hypersensitivity inflammation pathological pain skin barrier function hair growth gain-of-function mutations dermatitis alopecia androgen receptor activation androgenic alopecia skin cells pain perception skin structure hair structure TRPV3 blockers heat sensitivity chronic pain skin protection hair development genetic mutations skin inflammation hair loss hormone receptor activation male pattern baldness
Studysummary This review discusses the expanding understanding of TRPV3's role in pain and skin pathology, while highlighting the need for further pharmacological research to fully resolve its functions.
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