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    Efficacy of Placental-Derived Mesenchymal Stem Cell Exosome Therapy in Treating Androgenetic Alopecia: A Clinical Trial Study

    December 2024 in “ Research Square (Research Square) ”
    Leila Dehghani, Shahla Rostamirad, Ali Asilian … Masoud Soleimani

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this phase I/II clinical trial, placenta-derived mesenchymal stem cell exosome therapy significantly improved hair density and diameter, and reduced hair loss in patients with androgenetic alopecia, though further large-scale studies are needed to confirm these results and investigate the underlying molecular mechanisms.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 15

    1. Treatment of Androgenetic Alopecia by Exosomes Secreted From Hair Papilla Cells and the Intervention Effect of LTF Journal of Cosmetic Dermatology · 2023
    2. Systematic Review of Exosome Treatment in Hair Restoration: Preliminary Evidence, Safety, and Future Directions Journal of Cosmetic Dermatology · 2023
    3. Cell Therapy for Androgenetic Alopecia: Elixir or Trick? Stem cell reviews and reports · 2023
    4. Androgenetic Alopecia: Therapy Update Drugs · 2023
    5. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    6. Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia Pharmaceutics · 2022
    7. Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration Tissue Engineering and Regenerative Medicine · 2021
    8. Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion Nutrients · 2021
    9. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    10. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    11. Advances in Stem Cell-Based Therapy for Hair Loss PubMed · 2020
    12. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    13. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    14. Androgenetic Alopecia and Current Methods of Treatment PubMed · 2005
    15. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002